卖火柴的小女孩主要内容来曲唑和氯米芬临床促排卵效果的比较

2020年12月23日发(作者：学生喝什么奶粉好?已解决)
来曲唑和氯米芬临床促排卵效果的
比较
【摘要】 目的 比较芳香化酶抑制剂
——来曲唑和氯米芬促排卵的临床疗效。方
法 将62例不孕妇女随机分成 2组，其中来
曲唑组28例，氯米芬组34例，2组分别于
月经周期第3～7天每天口服来曲唑 mg或氯
米芬50 mg，均于月经第11天开始阴道B超
监测卵泡大小和子宫内膜厚度。至最 大卵泡
平均直径≥18 mm时，肌注人绒毛膜促性腺
激素10000 U。结果 肌注HCG 当日最大卵泡
MFD、周期排卵率、异位妊娠率2组比较，
差异无统计学意义。来曲唑组HCG 日优势卵
泡数、HCG日子宫内膜厚度、宫颈黏液评分、
临床周期妊娠率均优于氯米芬组。其中 来曲
唑组发生未破卵泡黄素化综合征1例，而氯
米芬组有3例。2组均未出现卵巢过度刺激综合征。结论 来曲唑用于不孕妇女的促排
卵治疗优于氯米芬，将来有可能替代氯米芬
作为 一线的诱发排卵药物。
【关键词】 不孕症；来曲唑；氯米芬；促
排卵药物
Abstract： Objective To compare the
clinical effects of letrozole (LE) and
clomiphene citrate (CC) on ovulation
induction. Methods 62 infertile women
with type Ⅱ reproductive endocrine
abnormality were randomly divided into
two groups, with 28 women in LE group and
34 women in CC group. The women in both
groups took mg letrozole and 50 mg
clomiphene citrate respectively, once a
day successively from the third to the
seventh day of menstrual period (5 days).
The follicle diameter and endometrial
thickness were monitored by the
transvaginal ultrasound as of the
eleventh day. When the max follicle
diameter (MFD) was ≥18 mm, the women
were injected with human chorionic
gonadotropin (HCG) 10000 U
intramuscularly. Results No significant
difference was found between the two
groups in MFD on HCG days, cycle
ovulation rate and ectopic pregnancy
rate (). LE group had the higher average
dominant follicle numbers, endometrial
thickness on HCG days, cervical mucus
scores and clinical pregnancy rate than
CC group (). There was one patient with
luteinized unruptured follicle syndrome
(LUFS) in LE group and three in CC group.
Neither of the groups had ovary
overstimulation syndrome. Conclusion
Letrozole has more advantage than
clomiphene citrate in ovulation
treatment of infertile women. It is
expected to replace clomiphene citrate
as a first-line drug to induce ovulation.
Key words: infertility; letrozole;
clomiphene citrate; ovulation induction
排卵障碍是引起不孕的主要原因之一。氯
米芬(CC)是目前临床应 用最广的促排卵药
物，但其对子宫内膜和宫颈黏液有潜在的不
良影响，使其促排卵率高但妊娠率 并不理想。