化痰药物氨溴索的非化痰作用研究进展

2020年12月12日发(作者：邱霍泉)
化痰药物氨溴索的非化痰作用研究进展
梁笛


【期刊名称】《复旦学报（医学版）》

【年(卷),期】2011(038)006

【摘要】Ambroxol is widely used as a mucolytic agent in respiratory
disease. Besides its mucolytic property, other pharmacological effects
have also been the focus of recent researches. Ambroxol, a powerful
anti-oxidative agent, neutralizes oxidative and nitrosative stress and
reduces tissue lipid peroxidation. Ambroxol is also an anti- inflammatory
agent which significantly reduces pro-inflammatory
cytokines,chemotaxis and respiratory burst of inflammatory cells.
Ambroxol increases production and secretion of pulmonary surfactant
as well. In addition, its effects include suppression of anti-allergy,
suppression of respiratory virus replication, interference with the biofilm
of pseudomonas aeruginosa, local anaesthetic effect and so on. Many
mechanisms of ambroxol's pharmacological effects have not been
clarified thoroughly,and more researches are needed.%氨溴索是呼吸系统
疾病的常用药物,其祛 痰作用已广为人知,并得到广泛应用.近年来氨溴索的各种
其他药理作用也得到了广泛关注.氨溴索具有 较强的抗氧化作用,能够直接清除体
内自由基等氧化物；氨溴索有一定的抗炎作用,对于气道炎症性疾病 有治疗作用；
氨溴索还可以促进肺泡表面活性物质的合成与分泌.此外,氨溴索还具有抗超敏反
应的作用,抗病毒和铜绿假单胞菌等病原体的作用,以及对细胞膜表面钠离子通道